Case Report by our Vice President, Dr. Shinichiro Yoshimine, published on Research Square

A case report by our Vice President, Dr. Shinichiro Yoshimine, has been published on Research Square, a preprint platform. It was posted on January 6, 2026 and is available as a Case Report.

This report summarizes the clinical course of a patient with chronic granulomatous apical periodontitis treated with adjunctive therapy combining intraoperative irrigation with ozonated water and local application of ozonized glycerin. The manuscript describes postoperative findings (pain, swelling, bleeding), wound-healing progression, and sequential imaging findings in chronological order. The authors note that this adjunctive approach may contribute to improved wound-healing quality and may help reduce the risk of recurrent infection.

Title:Adjunctive Therapy Using Ozonated Water and Ozonized Glycerin for Chronic Granulomatous Apical Periodontitis

Reference URL:

https://www.researchsquare.com/article/rs-8416245/v1